Travelling
Hi, I’m
DANIELA NATALE
Principal Research Scientist
ROMA
Summary
Challenges lover and results-oriented scientist with 9+ years experience in a Contract Research Organization. Extensive hands-on experience in cell biology and immuno-oncology. Highly adaptable relationship builder and excellent communicator, fast learner, willingness to seek new learning opportunities and responsabilities.
Overview
13
years of professional experience
10
years of post-secondary education
3
Languages
Work History
IRBM - Oncology UnitPomezia
Principal Research Scientist
03.2022 - Current
Job overview
- Support drug discovery programs by providing relevant scientific and strategic input by designing and executing relevant immune assays and immuno-profiling experiments for Immuno-Oncology projects
- Characterization of tumor micro-environments with multi-color flow cytometry
- Streamlined research processes to meet tight deadlines for multiple projects
- Wrote research papers, reports and summaries regarding projects in immunology and oncology
- Expanded cross-functional organizational capacity by collaborating across departments on priorities, functions and common goals
- Performed research into study topics to increase knowledge and to provide valuable contributions
- Responsible of the Flow Cytometry and Cell Sorting Platform: oversee all aspects of method development, troubleshooting, validation and sample analysis for research studies requiring flow cytometry
- Documented and reported test results after making graphical solutions and representations.
- Developed and maintained relationships with customers and suppliers
- Provided detailed technical and operational direction in project challenges, consistently meeting deliverables according to deadlines
- Made decisions independently and collaboratively on projects-related challenges
IRBM S- Discovery Biology Department
Principal Research Scientist
01.2019 - 03.2022
Job overview
- Design and perform flow cytometry and cell based experiments to support a bespoke assay service in human and mouse immunology, including immune-oncology
- Provide training and technical support to researchers across IRBM teams for FACS-based cell isolation and characterization associated with in vitro and in vivo studies
- Support scientists with presentations/reports/data analysis for all flow cytometry-based studies
- Maintaining and trouble-shooting cutting-edge equipment (FACS Canto II, FACS Aria III, Elispot)
- Performed research activities for Antibodies Screening programs in High-Throughput mode (HTS)
- Collaborated with leadership team to identify relevant questions and determine best methods of collection
- Generated data models and performed analysis to produce reports outlining results
IRBM - Translational research DepartmentRome
Research Scientist
01.2013 - 01.2018
Job overview
- Support small molecules screenings by providing scientific input, conduct and execute research activities for assay target selection, design and validation
- Manage a scientific team of 2-3 FTE’s (senior scientists and research associates)
- Oversaw and developed different research projects
- Writing manuscripts for scientific publication, project reports and conference presentations
- Collaborated with leadership team to identify relevant questions and determine best methods of collection
- support the establishment of FACS facility
- Responsible for maintaining cutting-edge equipments, provide training and technical support to researchers
- Perform multi-colour flow cytometric cell sorting and FACS experiments
- Analyze and interpretate experimental data by using of FACS analysis softwares (FlowJo, Modfit, FCS Express)
I.I.S. Cartesio Luxemburg
Chemistry Teacher
10.2012 - 10.2012
Job overview
- Evaluated and revised lesson plans and course content to achieve student-centered learning.
- Participated in department meetings to provide input to colleagues about student achievement and improvement.
- Prepared plans, materials and activities for students to reach chemistry learning outcomes.
Catholic University of Rome, Bambino Gesù Children’s HospitalRome
AIRC Postdoctoral Fellow
04.2010 - 09.2012
Job overview
- Investigation of the mechanism underlying immunosurveillance escape of cancer and the related role of the enzyme indoleamine 2,3 dioxygenase (IDO) in adult and pediatric patients with hematological malignancies
- Isolation of peripheral blood mononuclear cells (PBMCs) using Ficoll
- Generation of dendritic cells from isolated monocytes
- Analysis of cell populations by Flow Cytometry (BD FACS Canto II) in biological samples (blood and bone marrow from pediatric patients)
- Preparation of biological samples for High Performance Liquid Cromatography
- Western Blots and immunofluorescence
- Learned new skills and applied to daily tasks to improve efficiency and productivity
Theodor Kocher Institute - University of BernBern
Marie Curie Postdoctoral Fellowship
01.2008 - 02.2010
Job overview
- In vivo analysis of lymphocytes migration by combining quantum dot technology and twophoton microscopy
- Synthesis of antibody-nanoparticle conjugates
- Agarose gel electrophoresis for antibody purification
- Cleaning of mouse lymph nodes and preparation of their cryosections
- Cells isolations from mice
- Immunofluorescence of cells and tissue sections, fluorescence microscopy and in vivo multiphoton imaging
- Video processing and analysis (softwares: ImageJ and Volocity)
- Identified issues, analyzed information and provided solutions to problems.
- Collaborated with team members to achieve target results.
Education
University of Edinburgh
PhD
09.2004 - 12.2008
School of Chemistry, University of Naples Federico II
Master of Science
Degree from Chemistry
09.1997 - 10.2003
Skills
Critical thinkingundefined
Interests
Photography
Shiatsu (IES student)
Meditation
Artistic activities
Timeline
Principal Research Scientist
IRBM - Oncology Unit
03.2022 - Current
Principal Research Scientist
IRBM S- Discovery Biology Department
01.2019 - 03.2022
Research Scientist
IRBM - Translational research Department
01.2013 - 01.2018
Chemistry Teacher
I.I.S. Cartesio Luxemburg
10.2012 - 10.2012
AIRC Postdoctoral Fellow
Catholic University of Rome, Bambino Gesù Children’s Hospital
04.2010 - 09.2012
Marie Curie Postdoctoral Fellowship
Theodor Kocher Institute - University of Bern
01.2008 - 02.2010
University of Edinburgh
PhD
09.2004 - 12.2008
Degree from Chemistry
09.1997 - 10.2003
School of Chemistry, University of Naples Federico II
Master of Science
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