Anna Geraghty, PhD
Instructor
Stanford,CA
Summary
Highly organized interdisciplinary scientist specializing in neural-immune interactions in health and disease. Hardworking and proficient in conducting laboratory and animal experiments while mentoring new students on research methods and data collection procedures.
Overview
15
15
years of professional experience
10
10
years of post-secondary education
Work History
Instructor
Stanford University
Palo Alto, CA
10.2021 - Current
- Department of Neurology. Advisor: Dr. Michelle Monje, MD PhD
- Leading several multi-lab collaborations coordinating with an active clinical trial run by Dr. Monje aimed at identifying improvements in CAR T-cell immunotherapy efficacy in real time. These projects utilize patient samples and data to design and run rodent experiments, testing and generating new hypotheses for improving treatment of pediatric gliomas with the intention of bringing these treatment modifications back into the clinic.
- Under the guidance of Dr. Monje, coordinating and managing the launch of a new field of research in the lab investigating neural immune interactions after mild respiratory illnesses such as COVID and influenza. This multi-disciplinary effort brings together multiple labs across institutions in the US to collaborate.
- Training and mentoring multiple PhD students, postdocs and clinical research fellows across a wide range of projects, particularly in establishing new-to-us respiratory illness models and research.
Postdoctoral Research Fellow
Stanford University
Palo Alto, CA
09.2015 - 10.2021
- Department of Neurology. Advisor: Dr. Michelle Monje, MD PhD
- Investigated the mechanism through which neuronal activity regulates adaptive myelination in cortical projection neurons and how dysfunction of myelin plasticity contributes to cognitive disease, namely chemotherapy-related cognitive impairment (CRCI) or “chemobrain”.
- Identified BDNF-TrkB signaling as a required component of activity-dependent myelination and probed the role of myelin plasticity in non-motor cognitive function using genetic mouse models and optogenetic techniques.
- Investigated mechanisms of long-term cognitive impairment after CAR-T immunotherapy for brain and blood cancers, establishing within the lab a functional CAR T-cell research program.
- Designed research projects and wrote and published peer-reviewed articles
Graduate Research
University Of California, Berkeley
Berkeley, CA
08.2009 - 05.2015
Advisor: Dr. Daniela Kaufer, PhD
Thesis: The Role of RFRP-3 in chronic stress induced reproductive dysfunction and astrocyte communication
- Investigated CNS neurobiology of the hypo-pituitary-gonadal axis (HPG) and regulation of reproductive physiology by long-term chronic unpredictable stress
- Utilized behavioral assays for testing fecundity in female rats after stress
- Probed the neuroendocrine disruptions in hypothalamic reproductive regulation after chronic stress using viral manipulations, immunohistochemistry and gene and protein expression changes in a rat model.
- Supervised and trained undergraduates, designed research projects and wrote peer-reviewed publications
Undergraduate Research Assistant
University Of California, Berkeley
Berkeley, CA
01.2007 - 05.2009
2007-2009 Department of Integrative Biology, University of California, Berkeley
Advisor: Dr. Daniela Kaufer, PhD
- Investigated the functional connection between the stress neuroendocrine response and a novel hypothalamic reproductive inhibitory hormone, GnIH in rats using immunohistochemistry and gene expression changes.
2007 Department of Integrative Biology, University of California, Berkeley
Advisor: George Bentley, PhD
- Studied seasonal variations in reproductive hormones in starlings using immunohistochemistry.
Education
Ph.D. - Integrative Biology
University of California, Berkeley
Berkeley, CA 08.2009 - 05.2015
Bachelor of Arts - Integrative Biology
University of California, Berkeley
Berkeley, CA 08.2005 - 05.2009
Skills
Project Management
undefinedSelected Research Publications
1. Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022 Jul 7;185(14):2452-2468.e16. doi: 10.1016/j.cell.2022.06.008. Epub 2022 Jun 13. PMID: 35768006; PMCID: PMC9189143.
2. Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, Schultz LM, Richards RM, Jiang L, Barsan V, Mancusi R, Geraghty AC, Good Z, Mochizuki AY, Gillespie SM, Toland AMS, Mahdi J, Reschke A, Nie EH, Chau IJ, Rotiroti MC, Mount CW, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S, Fisher PG, Campen CJ, Filbin MG, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, Monje M. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature. 2022 Mar;603(7903):934-941. doi: 10.1038/s41586-022-04489-4. Epub 2022 Feb 7. PMID: 35130560; PMCID: PMC8967714.
3. Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, Lattin J, Xu P, Huang J, Nasholm N, He A, Kuo TC, Sangalang ERB, Pons J, Barkal A, Brewer RE, Marjon KD, Vilches-Moure JG, Marshall PL, Fernandes R, Monje M, Cochran JR, Sorensen PH, Daldrup-Link HE, Weissman IL, Sage J, Majeti R, Bertozzi CR, Weiss WA, Mackall CL, Majzner RG. Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. Nat Med. 2022 Feb;28(2):333-344. doi: 10.1038/s41591-021-01625-x. Epub 2022 Jan 13. PMID: 35027753; PMCID: PMC9098186.
4. Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, Tam LT, Espenel C, Ponnuswami A, Ni L, Woo PJ, Taylor KR, Agarwal A, Regev A, Brang D, Vogel H, Hervey-Jumper S, Bergles DE, Suvà ML, Malenka RC, Monje M. Electrical and synaptic integration of glioma into neual circuits. Nature. 2019 Sep;573(7775):539-545.
5. Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M. Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment. Neuron. 2019 Jul 17;103(2):250-265.e8.
6. Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC, Goldstein AK, Ni L, Woo PJ, Barres BA, Liddelow S, Vogel H, Monje M. Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation That Underlies Chemotherapy-Related Cognitive Impairment. Cell. 2019 Jan 10;176(1-2):43-55.e13.
7. Calisi RM, Geraghty AC, Avila A, Kaufer D, Bentley GE, Wingfield JC. Patterns of Hypothalamic GnIH Change Over the Reproductive Period in Starlings and Rats. Gen Comp Endocrinol. 2016 Oct 1;237:140-146.
8. Geraghty AC, Muroy SE, Kriegsfeld LJ, Bentley GE, Kaufer D. The role of RF-amide related peptide-3 in reproductive decline in female rats. Front Endocrinol (Lausanne). 2016 Jun 21;7:71.
9. Geraghty AC, Muroy SE, Zhao S, Bentley GE, Kriegsfeld LJ, Kaufer D (2015). Knockdown of hypothalamic RFRP3 prevents chronic stress induced infertility and embryo resorption. eLife. 2015 Jan 12; 4.
10. Chetty S, Friedman A, Kirby ED, Taravosh-Lahn K, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty AC, Krishnamurthy A, Tsai MK, Covarrubias D, Wong A, Francis DD, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Molecular Psychiatry. 19(12):1275-83.
11. Kirby ED, Geraghty AC, Ubuka T, Bentley GE, Kaufer D (2009) Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats. Proc Natl Acad Sci USA. 106 (27): 11324-11329.
Chapters and reviews
1. Gibson EM, Geraghty AC, Monje M. Bad Wrap: Myelin and Myelin Plasticity in Health and Disease. Dev Neurobiol. 2018 Feb;78(2):123-135.
2. Geraghty AC, Kaufer D (2015) Glucocorticoids and Reproduction. In: Glucocorticoids. Edited by Wang and Harris. Publisher: Springer, Adv Exp Med Biol. 2015;872:253-78.
Invited Talks and Conferences
- Invited Speaker. Stanford Stem Cell Group. 2020
- Poster Presentation. XIV European Meeting on Glial Cells in Health and Disease. 2019
- Poster Presentation. Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease. 2019
- Invited Speaker. Stanford Stem Cell Group. 2016
- Poster Presentation. Society for Neuroscience, 2013.
- Poster Presentation. Society for Behavioral Neuroendocrinology, 2012.
- Invited Speaker. UC Berkeley Neuroscience Retreat. 2012
- Poster Presentation. Society for Neuroscience, 2010.
- Poster Presentation. Society for Neuroscience, 2009.
- Poster Presentation. Society for Neuroscience, 2007.
Awards
2019-2021 Waxman Fund for Brain Tumor Research
2016-2017 Child Health Research Institute Postdoctoral Fellowship
2015-2018 Genentech Foundation/Bio-X Postdoctoral Fellowship
2010-2011 Outstanding Graduate Student Instructor, University of California, Berkeley
2009 Undergraduate Research Apprenticeship Program Award , Laboratory of Daniela Kaufer,
2008 Biology Fellows Award, Biology Scholars Program, University of California,
Teaching Experience
2009-2014 Graduate Student Instructor, University of California Berkeley
· 2014: Neurobiology of Stress
· 2014: Human Physiology
· 2010-2011: Biology of Stress
· 2009: Comparative Endocrinology
Timeline
Instructor
Stanford University
10.2021 - Current
Postdoctoral Research Fellow
Stanford University
09.2015 - 10.2021
Graduate Research
University Of California, Berkeley
08.2009 - 05.2015
Ph.D. - Integrative Biology
University of California, Berkeley
08.2009 - 05.2015
Undergraduate Research Assistant
University Of California, Berkeley
01.2007 - 05.2009
Bachelor of Arts - Integrative Biology
University of California, Berkeley
08.2005 - 05.2009
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